NEWS
MVPapp 0.4.7 (2026-10-03)
Features
- Maximum upload dataset size (in MB) can now be set by the
max_dataset_size argument, with a default value of 200 (#25)
Bugfixes
- Correcting some tooltips not being displayed properly (#24)
MVPapp 0.4.6 (2026-10-01)
Features
- Supports server-side dataset upload to be compatible in a validated environment (#22)
- QoL additions to the standalone .zip bundle (#23)
Bugfixes
- Correcting a behavior where doses with infusion rates would fail to display properly in individual plots (#21)
MVPapp 0.4.5 (2026-09-26)
Features
- Overhauled the Download Model button to have all relevant information in a standalone .zip bundle, together with a built-in R script to allow full reproducibility (#19)
Documentation
- AI Translation feature had its performance evaluated and documented in its vignette with results available on GitHub (#20)
MVPapp 0.4.4 (2026-09-19)
Features
- Automatic Change From Baseline (CFB) derivations for uploaded datasets using the DV column, per ID and CMT (using the first instance of EVID == 0, if present) (#18)
- Separating the original character-type ID column into USUBJID and a numeric ID column for simulation outputs to make it more NONMEM friendly (#16)
Bugfixes
- Dosing information now correctly included in all simulation outputs such that outputs are NONMEM-ready (#15, #17)
QoL Changes
- Extra download button for demographics for easier-access directly on the Demographics tab in Variability page (#14)
- Updated the model code for the "2 Compartment PK/PD (Indirect Effect)" model to be more general
- Updated default LLM model names
MVPapp 0.4.3 (2026-08-13)
Features
- Supporting the use of covariate distributions (or EBEs) from uploaded datasets in variability simulations (#13)
Bugfixes
- Fixing an issue where summary statistics with a non-numeric ID column are collapsed into the same subject (#12)
MVPapp 0.4.2 (2026-08-03)
Bugfixes
- Fixed an issue where LLM model translation fails for thinking models (#11)
MVPapp 0.4.1 (2026-03-15)
Features
- Deterministic translation from NONMEM files using nonmem2mrgsolve and nonmem2rx (#10)
MVPapp 0.4.0 (2026-03-02)
Features
- Automatic model translation using LLMs (#4)
- Supports Saving / Loading sessions (#5)
Bugfixes
- Minor bugfixes and general performance improvements. (#3)
- Plotly compatibility check with ggplot2 >=4.0.0 (#6)
MVPapp 0.3.5 (2026-02-04)
Bugfixes
- Dosing info now displays correctly for all doses in Individual Plots (#2)
MVPapp 0.3.4 (2025-12-02)
Features
- Covariate histograms feature in Data Exploration (#1).
MVPapp 0.3.3 (2025-07-31)
Features
- NHANES database updated to include 2021-2023, which brings it to approx. 100k real subjects available for sampling (#1)
- BMI filtering support for external databases
- Supports running app directly without installation (moved a few uncommon dependencies to suggests instead)
Bugfixes
- Correct typos for tooltips
- Corrected CV% for summary statistics to always report as absolute values
- Applying the distinct by ID built-in filter last for uploaded datasets (#47)
- Corrected behavior of range filters for filtered data display when a scroll bar is used (#48)
MVPapp 0.3.2 (2025-06-13)
Features
- Spider plot functionality added for batch runs (#46)
MVPapp 0.3.1 (2025-06-12)
Bugfixes
- Weight-based dosing now correctly apply for batch runs and variability simulations (#6)
MVPapp 0.3.0 (2025-06-09)
Features
- Implemented Batch runs (Parameter Sensitivity Analysis Page - All Parameters) to assess all parameters in the model with a defined upper/lower range in a single click (#44)
- QoL features includes fixing parameters, reset entire table, multiple display scales, and other graphical options
Bugfixes
- General performance improvements for larger models with long sampling (#43)
- Stability and minor UI fixes
MVPapp 0.2.19 (2025-06-03)
Features
- Re-worked median line bins to be based on quantiles (#37, #38)
- Built-in data filtering option to distinct by ID (#40)
- More QoL options for NCA (safeguards and rounding) (#41)
- Minor re-factoring and other QoL updates
Bugfixes
- Prevent non-sensible parameter estimates from crashing the entire app (#42)
- Bug fixes for General Plot's box plot count labels (#39)
- Better handling of NAs for Quantize X-axis option in General Plot
MVPapp 0.2.18 (2025-04-21)
Features
- New option for individual plots to identify outliers (#36)
- New option for individual plots to sort by one or more variables (#35)
- Additional tooltips for several options
- Separate plot titles for general and individual plots
- New template model (Parallel zero/first-order absorption model)
Bugfixes
- Fixed a bug where NCA would fail if dosing rows are not excluded by default (#33)
- Safeguard for simulating too many samples, with a default value of max 20000 samples (#32)
- NCA is now sorted by the grouping variable, followed by the dose column (#34)
MVPapp 0.2.17 (2025-03-13)
Features
- New option to split X-axis into quantiles for Data Page General Plots (#30)
- More template models (QS TMDD, MM TMDD).
Bugfixes
- Allows age and/or weight range sliders in Variability page to be the same value (#29)
- Re-worded some tooltips to improve clarity.
MVPapp 0.2.16 (2025-03-04)
Features
- Implement a short delay for some inputs to avoid frequent computations (#28)
Bugfixes
- Corrected code for Michaelis-Menten example (#27)
MVPapp 0.2.15 (2025-02-26)
Features
- Filter per column in Data Page (#26)
Bugfixes
- Handle duplicated column names in an uploaded dataset (#23)
- Properly display log y-axis with same scale when dosing info is displayed for Individual Plots (#25)
Other
- The built-in filter for removing EVID rows now uses
EVID >= 1, instead of EVID == 1 | EVID == 4
MVPapp 0.2.14 (2025-02-07)
Features
- Additional tab for Variability plots to display box plots of exposures (#22)
Bugfixes
- Minor updates to some tooltips and button placements to increase clarity.
MVPapp 0.2.13 (2025-02-04)
Features
- Dosing information, scaling, and LLOQ plotting options for Individual Plots (#18, #21)
- More options for dataset built-in cleaning (#20)
Bugfixes
- Checking for column validity for "Color by" option in General Plots (#19)
MVPapp 0.2.12 (2025-01-06)
Features
- Multiple facets for General Plots (#17)
- Individual plots for exploring uploaded datasets (#15)
- Mean trend toggle for variability plots (#13)
- Progress bars for longer computations where a spinner graphic is not feasible (#16)
Bugfixes
- Allow "Total Doses" for each Dosing Regimen to be 0 (#14)
MVPapp 0.2.11 (2024-12-04)
Features
- Support for uploading tab-delimited .txt files on Data Upload, with the option to automatically create ID column. (#9)
- Uses dose column instead of manually entering dose amount for NCA.
- Download Options now support non-interactive plots, with a dedicated "Download Non-Interactive Plot" button. (#11)
Bugfixes
- NCA Clearance unit corrected to be based on the supplied time unit.
- Linear regression is center aligned for ggplots (#10)
MVPapp 0.2.10 (2024-11-28)
Features
- Less strict requirements for Data Exploration plots to only require "ID" column to be present (previously would require "ID", "DV", and "TIME").
- Interactive plot toggle for Simulation and Data page plots.
- Boxplot functionality for Data Exploration - Plot Output. (#7)
- Text size option for labels (affects linear regression formulae and boxplot counts (N=x) only).
Bugfixes
- Fixed some typos.
- Most selectizeInputs now sort alphabetically.
Other
- Suggests mrgsolve v.1.5.2 to be installed.
MVPapp 0.2.9 (2024-10-25)
Features
- Upgraded Data Input - Plot Output tab, supporting facets, smoothers, and linear regression. (#5)
Bugfixes
- Fixed display error when model does not compile for PSA plots. (#2)
- Fixed wrong behavior for median lines binning. (#4)
- Consistently include dates for all downloadable items.
MVPapp 0.2.8 (2024-10-14)
Features
- More template models (1 CMT lag time).
- Increasing default decimal places (3 -> 5) for variability quantiles.
- Supports $PRED syntax. When model has $PRED syntax, dosing amounts will be disabled.
- Using recover = TRUE by default to output more helpful error messages when mrgsolve does not compile.
Bugfixes
- Bugfix for WT-based dosing to propagate correctly to Parameter Sensitivity Analysis when WT is a parameter (Note: currently WT-based dosing remains unsupported in Variability simulations).
MVPapp 0.2.7 (2024-09-30)
- GitHub release
- Minor bugfixes and optimizations