{
  "_id": "6ad5752dd423e4b0c576c166",
  "Package": "MVPapp",
  "Title": "Interactive Platform for Pharmacometrics Model Visualization and\nSimulation",
  "Version": "1.0.0",
  "Authors@R": "c(\nperson(\"Steve\", \"Choy\", email = \"steve.choy@outlook.com\", role = c(\"aut\", \"cre\", \"cph\")),\nperson(\"Jin Gyu\", \"Kim\", role = \"aut\"),\nperson(\"Matthew\", \"Fidler\", role = \"ctb\"),\nperson(\"Jason\", \"Bryer\", role = c(\"ctb\", \"cph\"),\ncomment = \"Author of the ShinyDemo package, from which run_mvp() is adapted\"))",
  "Description": "An interactive 'shiny' application for exploring\npharmacometrics models with minimal setup. Users can explore\nmodel structures, parameters and dosing regimens with\n'mrgsolve', and compare simulations with observed data.\nAdditional features include parameter sensitivity analysis,\nnon-compartmental analysis (NCA), data exploration, variability\nassessment with virtual populations, and optional AI-assisted\nmodel translation. For design considerations of the app, see\nChoy et al. (2025) <doi:10.1002/psp4.70023>.",
  "License": "GPL (>= 3)",
  "URL": "https://github.com/stevechoy/MVPapp,\nhttps://stevechoy.github.io/MVPapp/",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "Additional_repositories": "https://stevechoy.r-universe.dev",
  "LazyData": "true",
  "Collate": "\"utils-pipe.R\" \"utils.R\" \"ui_settings.R\" \"code_templates.R\"\n\"shiny_helpers.R\" \"plot_helpers.R\" \"data_utils.R\"\n\"plots_data.R\" \"simulation.R\" \"variability.R\" \"nca.R\"\n\"sensitivity.R\" \"llm.R\" \"session_state.R\" \"repro_bundle.R\"\n\"run_mvp.R\" \"zzz.R\" \"data.R\"",
  "VignetteBuilder": "knitr",
  "Config/testthat/edition": "3",
  "Language": "en-US",
  "Config/roxygen2/version": "8.0.0",
  "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev libfribidi-dev make libharfbuzz-dev libicu-dev\nlibjpeg-dev libpng-dev libtiff-dev libuv1-dev libwebp-dev\nlibxml2-dev libssl-dev zlib1g-dev",
  "Repository": "https://stevechoy.r-universe.dev",
  "Date/Publication": "2026-10-18 23:58:50 UTC",
  "RemoteUrl": "https://github.com/stevechoy/MVPapp",
  "RemoteRef": "HEAD",
  "RemoteSha": "7961064fb161a78f0a65305cdde3003d77f7b30d",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-19 01:35:38 UTC",
    "User": "root"
  },
  "Author": "Steve Choy [aut, cre, cph],\nJin Gyu Kim [aut],\nMatthew Fidler [ctb],\nJason Bryer [ctb, cph] (Author of the ShinyDemo package, from which\nrun_mvp() is adapted)",
  "Maintainer": "Steve Choy <steve.choy@outlook.com>",
  "_user": "stevechoy",
  "_type": "src",
  "_file": "MVPapp_1.0.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/e6cffafbd8517ac8c38de86528201d3ab1eb20476040b37c68ee9cd75715549b",
  "_filesize": 2284889,
  "_sha256": "e6cffafbd8517ac8c38de86528201d3ab1eb20476040b37c68ee9cd75715549b",
  "_expires": "2027-01-27T01:40:58.000Z",
  "_created": "2026-10-19T01:35:38.000Z",
  "_published": "2026-10-19T01:41:00.928Z",
  "_buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_jobs": [
    {
      "job": 117848747027,
      "time": 192,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "12158271896"
    },
    {
      "job": 117848747097,
      "time": 273,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12158346918"
    },
    {
      "job": 117848747008,
      "time": 171,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "12157769281"
    },
    {
      "job": 117848747050,
      "time": 159,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12158590549"
    },
    {
      "job": 117847746928,
      "time": 261,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12157654634"
    },
    {
      "job": 117848747075,
      "time": 165,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "12158276783"
    },
    {
      "job": 117848747117,
      "time": 168,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "12158206211"
    },
    {
      "job": 117848747015,
      "time": 143,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "12158550272"
    },
    {
      "job": 117848747202,
      "time": 183,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12158441178"
    }
  ],
  "_upstream": "https://github.com/stevechoy/MVPapp",
  "_commit": {
    "id": "7961064fb161a78f0a65305cdde3003d77f7b30d",
    "author": "Claude <noreply@anthropic.com>",
    "committer": "Claude <noreply@anthropic.com>",
    "message": "run_mvp(): drop the Note section (adapted code is credited in Authors@R)\n\nCo-Authored-By: Claude Sonnet 5.5 <noreply@anthropic.com>\nClaude-Session: https://claude.ai/code/session_01Em4bew8BXLieqYwB8TJR1o\n",
    "time": 1792367930
  },
  "_maintainer": {
    "name": "Steve Choy",
    "email": "steve.choy@outlook.com",
    "login": "stevechoy",
    "linkedin": "in/steve-choy-1011bb15",
    "description": "MIDD Lead",
    "uuid": 33142947
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.1",
      "role": "Depends"
    },
    {
      "package": "bslib",
      "version": ">= 0.5.1",
      "role": "Imports"
    },
    {
      "package": "cowplot",
      "role": "Imports"
    },
    {
      "package": "data.table",
      "version": ">= 1.14.2",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "version": ">= 1.1.0",
      "role": "Imports"
    },
    {
      "package": "DT",
      "role": "Imports"
    },
    {
      "package": "flextable",
      "version": ">= 0.6.10",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "version": ">= 3.4.4",
      "role": "Imports"
    },
    {
      "package": "grid",
      "role": "Imports"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "grDevices",
      "role": "Imports"
    },
    {
      "package": "htmltools",
      "version": ">= 0.5.5",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "mrgsolve",
      "version": ">= 1.5.0",
      "role": "Imports"
    },
    {
      "package": "plotly",
      "version": ">= 4.10.1",
      "role": "Imports"
    },
    {
      "package": "rhandsontable",
      "version": ">= 0.3.8",
      "role": "Imports"
    },
    {
      "package": "rlang",
      "version": ">= 1.0.0",
      "role": "Imports"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "shiny",
      "version": ">= 1.7.4.1",
      "role": "Imports"
    },
    {
      "package": "shinyAce",
      "role": "Imports"
    },
    {
      "package": "shinyBS",
      "version": ">= 0.61.1",
      "role": "Imports"
    },
    {
      "package": "shinycssloaders",
      "role": "Imports"
    },
    {
      "package": "shinydashboard",
      "version": ">= 0.7.2",
      "role": "Imports"
    },
    {
      "package": "shinyFiles",
      "role": "Imports"
    },
    {
      "package": "shinyjs",
      "version": ">= 1.0",
      "role": "Imports"
    },
    {
      "package": "shinythemes",
      "role": "Imports"
    },
    {
      "package": "shinyWidgets",
      "version": ">= 0.8.0",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "stringr",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "tools",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "zip",
      "role": "Imports"
    },
    {
      "package": "curl",
      "role": "Suggests"
    },
    {
      "package": "ellmer",
      "version": ">= 0.4.0",
      "role": "Suggests"
    },
    {
      "package": "GGally",
      "role": "Suggests"
    },
    {
      "package": "httr2",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "mime",
      "role": "Suggests"
    },
    {
      "package": "ncar",
      "role": "Suggests"
    },
    {
      "package": "NonCompart",
      "role": "Suggests"
    },
    {
      "package": "nonmem2mrgsolve",
      "role": "Suggests"
    },
    {
      "package": "nonmem2rx",
      "role": "Suggests"
    },
    {
      "package": "pdftools",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "shinyalert",
      "role": "Suggests"
    },
    {
      "package": "spelling",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    }
  ],
  "_owner": "stevechoy",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-48",
      "n": 5
    },
    {
      "week": "2025-49",
      "n": 3
    },
    {
      "week": "2025-50",
      "n": 1
    },
    {
      "week": "2026-06",
      "n": 1
    },
    {
      "week": "2026-09",
      "n": 16
    },
    {
      "week": "2026-10",
      "n": 4
    },
    {
      "week": "2026-11",
      "n": 29
    },
    {
      "week": "2026-12",
      "n": 9
    },
    {
      "week": "2026-23",
      "n": 2
    },
    {
      "week": "2026-29",
      "n": 1
    },
    {
      "week": "2026-32",
      "n": 2
    },
    {
      "week": "2026-33",
      "n": 5
    },
    {
      "week": "2026-36",
      "n": 6
    },
    {
      "week": "2026-37",
      "n": 1
    },
    {
      "week": "2026-38",
      "n": 3
    },
    {
      "week": "2026-39",
      "n": 6
    },
    {
      "week": "2026-40",
      "n": 11
    },
    {
      "week": "2026-42",
      "n": 88
    }
  ],
  "_tags": [
    {
      "name": "v0.3.4",
      "date": "2025-12-02"
    },
    {
      "name": "v0.3.5",
      "date": "2026-02-04"
    },
    {
      "name": "v0.4.0",
      "date": "2026-03-12"
    },
    {
      "name": "v0.4.1",
      "date": "2026-03-16"
    },
    {
      "name": "v0.4.2",
      "date": "2026-08-04"
    },
    {
      "name": "v0.4.3",
      "date": "2026-08-14"
    },
    {
      "name": "v0.4.4",
      "date": "2026-09-19"
    },
    {
      "name": "v0.4.5",
      "date": "2026-09-27"
    },
    {
      "name": "v0.4.6",
      "date": "2026-10-02"
    },
    {
      "name": "v0.4.7",
      "date": "2026-10-03"
    }
  ],
  "_topics": [
    "pharmacometrics",
    "shiny",
    "simulation"
  ],
  "_stars": 4,
  "_contributors": [
    {
      "user": "stevechoy",
      "count": 241,
      "uuid": 33142947
    },
    {
      "user": "claude",
      "count": 34,
      "uuid": 81847
    },
    {
      "user": "metmajer",
      "count": 1,
      "uuid": 873565
    },
    {
      "user": "mattfidler",
      "count": 1,
      "uuid": 514778
    }
  ],
  "_userbio": {
    "uuid": 33142947,
    "type": "user",
    "name": "Steve Choy",
    "followers": 5,
    "description": "MIDD Lead"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/MVPapp"
  },
  "_devurl": "https://github.com/stevechoy/mvpapp",
  "_pkgdown": "https://stevechoy.github.io/MVPapp/",
  "_searchresults": 7,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/MVPapp.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md"
  ],
  "_cranurl": false,
  "_exports": [
    "%>%",
    "mvp_app",
    "run_mvp"
  ],
  "_datasets": [
    {
      "name": "cdc.expand",
      "title": "CDC pediatric virtual population",
      "object": "cdc.expand",
      "class": [
        "data.frame"
      ],
      "fields": [
        "SEX",
        "AGEMO",
        "AGEYR",
        "WT",
        "HT",
        "BMI"
      ],
      "rows": 97177,
      "table": true,
      "tojson": true
    },
    {
      "name": "nhanes.filtered",
      "title": "NHANES population (1999-2023)",
      "object": "nhanes.filtered",
      "class": [
        "data.frame"
      ],
      "fields": [
        "SEX",
        "AGEMO",
        "AGEYR",
        "WT",
        "HT"
      ],
      "rows": 101400,
      "table": true,
      "tojson": true
    },
    {
      "name": "who.expand",
      "title": "WHO pediatric virtual population",
      "object": "who.expand",
      "class": [
        "data.frame"
      ],
      "fields": [
        "SEX",
        "AGEMO",
        "AGEYR",
        "WT",
        "HT",
        "BMI"
      ],
      "rows": 77744,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "cdc.expand",
      "title": "CDC pediatric virtual population",
      "topics": [
        "cdc.expand"
      ]
    },
    {
      "page": "nhanes.filtered",
      "title": "NHANES population (1999-2023)",
      "topics": [
        "nhanes.filtered"
      ]
    },
    {
      "page": "run_mvp",
      "title": "Launch Model Visualization Platform App",
      "topics": [
        "mvp_app",
        "run_mvp"
      ]
    },
    {
      "page": "who.expand",
      "title": "WHO pediatric virtual population",
      "topics": [
        "who.expand"
      ]
    }
  ],
  "_pkglogo": "https://github.com/stevechoy/MVPapp/raw/HEAD/man/figures/logo.svg",
  "_readme": "https://github.com/stevechoy/MVPapp/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "base64enc",
    "BH",
    "bslib",
    "cachem",
    "cli",
    "commonmark",
    "cowplot",
    "cpp11",
    "crosstalk",
    "curl",
    "data.table",
    "digest",
    "dplyr",
    "DT",
    "evaluate",
    "farver",
    "fastmap",
    "flextable",
    "fontawesome",
    "fontBitstreamVera",
    "fontLiberation",
    "fontquiver",
    "fs",
    "gdtools",
    "generics",
    "ggplot2",
    "glue",
    "gtable",
    "highr",
    "htmltools",
    "htmlwidgets",
    "httpuv",
    "httr",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "later",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "memoise",
    "mime",
    "mrgsolve",
    "officer",
    "openssl",
    "otel",
    "pillar",
    "pkgconfig",
    "plotly",
    "promises",
    "purrr",
    "R6",
    "ragg",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "rhandsontable",
    "rlang",
    "rmarkdown",
    "S7",
    "sass",
    "scales",
    "shiny",
    "shinyAce",
    "shinyBS",
    "shinycssloaders",
    "shinydashboard",
    "shinyFiles",
    "shinyjs",
    "shinythemes",
    "shinyWidgets",
    "sourcetools",
    "stringi",
    "stringr",
    "sys",
    "systemfonts",
    "textshaping",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "utf8",
    "uuid",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "xml2",
    "xtable",
    "yaml",
    "zip"
  ],
  "_vignettes": [
    {
      "source": "automatic-translation.Rmd",
      "filename": "automatic-translation.html",
      "title": "Automatic Model Translation",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Motivation",
        "Disclaimer",
        "Pre-requisites",
        "Setup",
        "Required Packages",
        "API Keys",
        "Configuring Default Options",
        "Usage",
        "Locally Parsing Files",
        "Automatic Retries",
        "Deterministic Translation of NONMEM files",
        "Cost",
        "Notes",
        "Performance Evaluation",
        "Summary"
      ],
      "created": "2026-02-25 03:13:28",
      "modified": "2026-10-18 19:45:09",
      "commits": 28
    },
    {
      "source": "data-exploration.Rmd",
      "filename": "data-exploration.html",
      "title": "Effective Exploratory Data Analysis",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Motivation",
        "Uploading and Filtering Data",
        "Summary Statistics",
        "Descriptive Statistics (NCA)",
        "General Plot",
        "Continuous Plots",
        "Box plots",
        "Count plots",
        "Individual Plots",
        "Correlation Plots",
        "Covariate Histograms",
        "Summary"
      ],
      "created": "2025-01-22 22:10:42",
      "modified": "2026-10-17 19:20:41",
      "commits": 11
    },
    {
      "source": "supply-passwords.Rmd",
      "filename": "supply-passwords.html",
      "title": "Supplying Passworded Models",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Update",
        "Motivation",
        "How models are supplied to MVP",
        "Re-defining model_switch_conditions()",
        "Re-defining update_model_choices()",
        "Data Options",
        "Dosing Options",
        "Sampling Options",
        "Plotting Options",
        "Variability Options",
        "Supplying Model Code",
        "Summary"
      ],
      "created": "2024-10-04 20:11:04",
      "modified": "2026-10-17 19:20:41",
      "commits": 16
    }
  ],
  "_score": 5.510545010206613,
  "_indexed": true,
  "_nocasepkg": "mvpapp",
  "_universes": [
    "stevechoy"
  ],
  "_previous": "0.4.7",
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0.0",
      "date": "2026-10-19T01:38:30.000Z",
      "distro": "resolute",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/f8fbfa8f9cdfdf88cce8bf16daa80c831d486b5d15f4a67a7e5eea0274939267",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.0.0",
      "date": "2026-10-19T01:39:32.000Z",
      "distro": "resolute",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/41b71bc1c89f54c6f71a7f7a984e3927d2232137b1677c5d3636b8adbf7f156e",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.0.0",
      "date": "2026-10-19T01:38:02.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/2e9b052afc4c3c6f9ec9ddac74bd7751d0751a736e4bbc2e42eeca7f807e6f2d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "1.0.0",
      "date": "2026-10-19T01:37:50.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/2b03d3abad3affd971ad00629026d36022a7454a3b3daa2e1660efeaae8d7d30",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0.0",
      "date": "2026-10-19T01:38:45.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/8007e7ff23ae2493d95e8c90fe5eec56a214630246d52b8316473a04084c5e42",
      "status": "success",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0.0",
      "date": "2026-10-19T01:37:39.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/f10e1d52e618039909080f71765997ab59b4a461213c226758b5637ee1511000",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.0.0",
      "date": "2026-10-19T01:37:17.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/e25fe3b5a1a02d3ee0dd25fb51af994b0682c067939292eebd10142a10f57865",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.0.0",
      "date": "2026-10-19T01:37:50.000Z",
      "commit": "7961064fb161a78f0a65305cdde3003d77f7b30d",
      "fileid": "https://r2.ropensci.org/8e83df03e9b84c41e6cd65a37e129c3506cf2fda90ee2cb6fcfc153a878fb85f",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/stevechoy/actions/runs/39185740624"
    }
  ]
}